8-CPT-2Me-cAMP, sodium salt 283psilon-(gamma-glutamyl)-lysine Action on the dopaminergic systems

Action on the dopaminergic systems makes it also potentially useful as an add-on therapy in major depressive disorder

In human tumor cell lines

(E/Z)-Demethoxycurcumin (p-Hydroxycinnamoyl-feruloylmethane) is a curcuminoid isolated from curcuma species

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Palyzová A

8-CPT-2Me-cAMP, sodium salt 283psilon-(gamma-glutamyl)-lysine Action on the dopaminergic systems8 CPT 2Me cAMP, sodium salt is a selective agonist of EPAC . Cyclic AMP guanine nucleotide exchange factors (EPACs) are intracellular sensors for cAMP and function as nucleotide exchange factors for the Ras GTPase homologues Rap1 and Rap2 . 8 CPT 2Me cAMP, sodium salt is a selective EPAC agonist. 8 CPT 2Me cAMP increased Rap1 activation by EPAC1. Meantime, light chain 2 (LC2) of the microtubule associated protein MAP1A increased this response. In LC2